Table I.
Examination of the relative indexes prior to and following treatment with N-acetylcysteine.
| A, Case 1 | |||
|---|---|---|---|
| Indexes | Pre-treatment | 8 weeks after treatment | 12 weeks after treatment |
| Weight (kg) | 77 | 70 | 65 |
| White blood cell (×109/l) | 2.5 | 3.4 | 3.9 |
| 24-h urine protein (g) | 2.1 | 1.8 | 1.0 |
| ESR (mm/h) | 56 | 40 | 32 |
| GSH (mg/g) | 0.46 | 0.95 | 1.13 |
| 8-iso-PGF2α (µg/l) | 66.3 | 50.5 | 56.7 |
| GFR (µl/min) | 105 | 106 | 93 |
| Creatinine (µmol/l) | 95 | 84 | 90 |
| Urinalysisa | pro3+ | pro2+ | pro1+ |
| SLEDAI | 9 | 8 | 4 |
| B, Case 2 | |||
| Indexes | Pre-treatment | 8 weeks after treatment | 12 weeks after treatment |
| Weight (kg) | 56 | 55 | 53 |
| White blood cell (×109/l) | 2.9 | 3.5 | 3.8 |
| 24-h urine protein (g) | 1.5 | 1.2 | 0.9 |
| ESR (mm/h) | 49 | 45 | 33 |
| GSH (mg/g) | 0.56 | 1.02 | 1.21 |
| 8-iso-PGF2α (µg/l) | 70.2 | 61.4 | 55.8 |
| GFR (µl/min) | 103 | 102 | 97 |
| Creatinine (µmol/l) | 63 | 70 | 65 |
| Urinalysisa | pro2+ | pro1+ | pro1+ |
| SLEDAI | 9 | 8 | 4 |
a
Hematuria, urinary casts and pyuria were not observed in urinalysis of either patient. ESR, erythrocyte sedimentation rate; GSH, glutathione; 8-iso-PGF2α, 8-iso-prostaglandin F2α; GFR, glomerular filtration rate; SLEDAI, systemic lupus erythematosus disease activity index; Pro, proteinuria; pro1+, proteinuria <0.3 g/l; pro2+, 0.3 g/l ≤ proteinuria≤1 g/l; pro3+, 1 g/l<proteinuria<5 g/l.