Table 6.
Behavioral and neuronal changes in NAc shell activity after repeated use of appetite suppressants
| Relative to Day Before Treatment |
||||||||
|---|---|---|---|---|---|---|---|---|
| Drug | Period | Change in bodyweight, g | 24-h Chow intake, % | Activity | Baseline | Saline | Drugs | |
| DEP20 | Day 1 | −9.5 ± 2.5 | −45.4 ± 13.8 | Firing rate, Hz | All (22) | 5.1 ± 0.02 | 4.9 ± 0.01 | 3.0 ± 0.02 |
| Inhibited (19) | 5.4 ± 0.01 | 5.4 ± 0.01 | 1.9 ± 0.04 | |||||
| Activated (3) | 2.4 ± 0.01 | 2.8 ± 0.01 | 4.6 ± 0.03 | |||||
| z-score (PSD) | Beta (15–30 Hz) | 0.030 ± 0.009 | 0.033 ± 0.008 | 0.638 ± 0.009 | ||||
| Theta (6–9 Hz) | 0.042 ± 0.008 | 0.187 ± 0.008 | 1.063 ± 0.012 | |||||
| Delta (1–4 Hz) | 0.020 ± 0.009 | 0.088 ± 0.008 | 1.519 ± 0.007 | |||||
| Distance, cm/min | 555 ± 24 | 383 ± 26 | 2088 ± 64 | |||||
| Days 2–7 | −12.3 ± 1.9 | −29.4 ± 4.2 | Firing rate, Hz | All (109) | 6.3 ± 0.01 | 6.6 ± 0.01 | 4.5 ± 0.03 | |
| Inhibited (87) | 5.6 ± 0.01 | 6.0 ± 0.01 | 2.0 ± 0.04 | |||||
| Activated (22) | 3.1 ± 0.01 | 3.0 ± 0.04 | 7.9 ± 0.18 | |||||
| z-score (PSD) | Beta | −0.017 ± 0.003 | −0.007 ± 0.008 | −0.455 ± 0.035* | ||||
| Theta | 0.012 ± 0.003 | 0.066 ± 0.004 | 0.008 ± 0.008* | |||||
| Delta | 0.013 ± 0.003 | 0.063 ± 0.004 | 0.918 ± 0.026* | |||||
| Distance, cm/min | 452 ± 19 | 448 ± 16 | 1382 ± 25 | |||||
| Days 8–14 | −1.8 ± 2.1* | −9.6 ± 2.9* | Firing rate, Hz | All (23) | 3.8 ± 0.003 | 3.7 ± 0.006 | 1.1 ± 0.003 | |
| Inhibited (23) | 3.8 ± 0.003 | 3.7 ± 0.006 | 1.1 ± 0.003 | |||||
| Activated (0) | ||||||||
| z-score (PSD) | Beta | −0.007 ± 0.005 | 0.001 ± 0.006 | −1.574 ± 0.019* | ||||
| Theta | 0.028 ± 0.004 | −0.008 ± 0.005 | −1.459 ± 0.008* | |||||
| Delta | 0.029 ± 0.004 | −0.069 ± 0.005 | −0.047 ± 0.017* | |||||
| Distance, cm/min | 280 ± 12 | 294 ± 14 | 1449 ± 24 | |||||
| PHEN20 | Day 1 | −1.7 ± 1.8 | −27.7 ± 3.5 | Firing rate, Hz | All (20) | 3.6 ± 0.02 | 3.3 ± 0.02 | 2.8 ± 0.01 |
| Inhibited (11) | 3.1 ± 0.002 | 2.6 ± 0.003 | 1.1 ± 0.01 | |||||
| Activated (1) | 0.9 ± 0.001 | 0.9 ± 0.001 | 2.0 ± 0.01 | |||||
| z-score (PSD) | Beta | 0.013 ± 0.008 | −0.061 ± 0.006 | 0.627 ± 0.022 | ||||
| Theta | 0.035 ± 0.006 | 0.017 ± 0.006 | 0.869 ± 0.009 | |||||
| Delta | 0.029 ± 0.006 | −0.089 ± 0.006 | 1.172 ± 0.022 | |||||
| Distance, cm/min | 240 ± 20 | 195 ± 11 | 572 ± 23 | |||||
| Days 2–7 | −0.5 ± 2.9 | −20.3 ± 3.8 | Firing rate, Hz | All (39) | 4.0 ± 0.01 | 4.1 ± 0.01 | 2.6 ± 0.01 | |
| Inhibited (27) | 4.4 ± 0.01 | 4.3 ± 0.01 | 1.9 ± 0.03 | |||||
| Activated (2) | 3.7 ± 0.01 | 3.4 ± 0.02 | 8.2 ± 0.06 | |||||
| z-score (PSD) | Beta | −0.004 ± 0.005 | 0.191 ± 0.008 | 1.051 ± 0.026* | ||||
| Theta | 0.027 ± 0.005 | 0.068 ± 0.006 | 0.848 ± 0.008 | |||||
| Delta | 0.012 ± 0.004 | −0.083 ± 0.007 | 1.079 ± 0.028 | |||||
| Distance, cm/min | 155 ± 12 | 218 ± 8 | 836 ± 43 | |||||
| BUP30 | Day 1 | −2.2 ± 1.1 | −15.7 ± 1.8 | Firing rate, Hz | All (18) | 5.8 ± 0.03 | 6.4 ± 0.03 | 6.7 ± 0.03 |
| Inhibited (9) | 3.5 ± 0.01 | 3.4 ± 0.01 | 1.6 ± 0.01 | |||||
| Activated (2) | 10.5 ± 0.03 | 12.6 ± 0.04 | 20.2 ± 0.05 | |||||
| z-score (PSD) | Beta | 0.011 ± 0.008 | 0.013 ± 0.007 | −0.245 ± 0.011 | ||||
| Theta | 0.055 ± 0.007 | 0.044 ± 0.007 | 0.297 ± 0.009 | |||||
| Delta | 0.037 ± 0.007 | −0.039 ± 0.007 | 0.508 ± 0.012 | |||||
| Distance, cm/min | 146 ± 10 | 102 ± 6 | 487 ± 28 | |||||
| Days 2–7 | 7.9 ± 4.1* | −12.8 ± 5.5 | Firing rate, Hz | All (92) | 5.1 ± 0.02 | 5.0 ± 0.02 | 5.1 ± 0.02 | |
| Inhibited (39) | 3.6 ± 0.01 | 3.7 ± 0.007 | 1.9 ± 0.03 | |||||
| Activated (14) | 5.3 ± 0.02 | 5.3 ± 0.02 | 9.4 ± 0.16 | |||||
| z-score (PSD) | Beta | −0.031 ± 0.005 | −0.0003 ± 0.006 | 0.383 ± 0.028* | ||||
| Theta | 0.071 ± 0.004 | −0.180 ± 0.004 | 0.060 ± 0.007* | |||||
| Delta | 0.049 ± 0.004 | −0.300 ± 0.004 | 0.116 ± 0.028* | |||||
| Distance, cm/min | 230 ± 10 | 188 ± 10 | 651 ± 24 | |||||
Values are means ± SE; no. of neurons is given in parentheses.
*
P < 0.05, comparison across periods.