Table 4.

Summary of the parameter values used in the simulation depicted in Figs. 2 and 3

Parameter	Description	Value	Units
C hyp	Threshold of hypoxia	5.5	M
$C_{\mathit{\text{hyp}}}^{\mathit{\text{sev}}}$	Threshold of severe hypoxia	1.52	M
C nec	Threshold of necrosis	0.02	M
D C,max	Maximum diffusion of oxygen	1	mm 2 h −1
D α,max	Maximum diffusion of VEGF	0.1875	mm 2 h −1
ε	Percentage of loss of diffusion	20	%
C sou	Oxygen concentration in functional blood vessels	8	M h −1
λ C	Degradation rate of oxygen	0.01	h −1
ε C	Rate of oxygen consumption by proliferative cells	3	cells −1 mm 2 h −1
β C	Rate of oxygen consumption by quiescent cells	1.5	cells −1 mm 2 h −1
C max	Maximum concentration of oxygen	8	M
λ α	Degradation rate of VEGF	1.25×10−4	h −1
π	Binding rate of VEGF to endothelial cells	0.791	cells −1 mm 2 h −1
α sou	Production rate of VEGF	2.11	M cells −1 mm 2 h −1
α max	Maximum concentration of VEGF	2.11	M
α half	Shape parameter of f ρρ	1.25×10−3	M
χ chemo	Maximum effect of VEGF on endothelial chemotaxis	1.25×10−2	mm 2 M −1 h −1
χ prol	Maximum effect of VEGF on endothelial proliferation	5×10−2	h −1