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. Author manuscript; available in PMC: 2015 Jul 21.
Published in final edited form as: Hepatology. 2010 Dec;52(6):2233–2236. doi: 10.1002/hep.24045

Figure 1.

Figure 1

Species blocks in HCV infection and phenotype of mtHCV. (A) HCV life cycle and blocks in murine cells. HCV entry and replication are blocked in murine cells, whereas endocytosis, membrane fusion, uncoating, translation, and polyprotein processing are supported. There are no data available on the assembly, maturation, and release of infectious HCV particles in murine cells. Capital letters indicate steps in the HCV life cycle that presumably require adaptation to the murine host. (B) Membrane topology model of HCV entry factors and entry factor usage by HCV and mtHCV. HCV entry requires four factors: SCARBI, CD81, CLDN1, and OCLN. The large extracellular loop (LEL) of CD81 and extracellular loops 1 and 2 (EL1 and EL2) of CLDN1 and OCLN, which are critical for HCV entry, are labeled. Entry factors restricting entry into mouse hepatocytes are depicted in light gray. The table shows human and mouse entry factor usage of parental HCV and adapted mtHCV (a check mark means that entry is supported, and a dash means that entry is blocked; h and m indicate human and mouse, respectively). Newly acquired tropisms of mtHCV are shaded in gray.