Table IV.
Intraoperative and postoperative parameters for patients undergoing isolated limb infusions
| Variable | Overall (N=26) | Upper Extremity (N=7) | Lower extremity (N=19) | P-value |
|---|---|---|---|---|
| Limb volume, median, range, L | 6.54 (1.4-11) | 2.4 (1.4-3.0) | 7.1 (6.5-10.3) | 0.003 |
| Melphalan dose, median, range, mg | 34 (20-44) | 19 (11.5-27) | 38 (20-65) | 0.002 |
| Dactinomycin dose, median, range, mg | 650 (140-900) | 233 (140-300) | 695 (320-900) | 0.001 |
| Melphalan dose adjusted for Ideal Body Weight, % | 96 | 100 | 95 | NS |
| Papaverine use intraoperatively, % | 100% | 100% | 100% | NS |
| Initial Limb Temp, ° Centigrade | 38.5 (37.1-39.8) | 38.5 (38.5-39.8) | 38.5 (37.1-39.4) | NS |
| Temp at 30 minutes, ° Centigrade | 39.5 (37.8-40.6) | 39.7 (39.4-40.2) | 39.4 (37.8-40.6) | NS |
| Perfusate blood gas at 30 minutes | ||||
| PaO2, median, range, mm Hg | 10 (5-38) | 15(7-38) | 9(5-10) | 0.02 |
| pH, median, range | 7.2 (6.97-7.28) | 7.08(7.06-7.25) | 7.2(6.97-7.28) | 0.03 |
| Base excess, median, range, mEq | -10 (-17, -3.8) | -15.3(-16.5, -7.9) | -7.1(-17, -3.8) | 0.006 |
| Ischemia time, minutes, range | 51 (46-73) | 53.5(44-60) | 50.5(47-73) | NS |
| Peak CPK, median, range, U/mL | 455 (82-1058) | 131 (69-184) | 607 (93-1135) | NS |
| Day of CPK peak, median, range | 4 (2-4.5) | 2 (1.5-4) | 4.5 (3-5.5) | 0.02 |
| Wieberdink toxicity | NS | |||
| Grade I-II | 18 (69%) | 6 (86%) | 12 (63%) | |
| Grade III | 6 (23%) | 0 (0%) | 6 (37%) | |
| Length of stay, days, range | 6 (5-10) | 5.5 (5-7) | 6 (5-10) | NS |
Abbreviations: CPK, Creatinine phosphokinase; NS, not significant