Figure 4.

Increased SR Ca²⁺ Load and SERCA Function in TG Myocytes

(A) Representative traces of [Ca²⁺]_i transient and decay by voltage clamp studies after a rapid application of caffeine to deplete sarcoplasmic reticulum (SR) Ca²⁺ stores. (B) Mean data for SR [Ca²⁺] load. (C) Average values of sarcoplasmic reticulum Ca²⁺-ATPase (SERCA) function by comparing the decay of the depolarization-induced Ca²⁺ transient with the decay of the caffeine-induced Ca²⁺ transient. *p < 0.05. **p < 0.01 versus TG basal. ##p < 0.01 versus WT/Ang II. Abbreviations as in Figure 1, Figure 3.