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. Author manuscript; available in PMC: 2015 Jul 21.
Published in final edited form as: Ther Deliv. 2010 Oct;1(4):517–534. doi: 10.4155/tde.10.50

Figure 3. The blood–brain barrier represents a significant obstacle to CNS gene delivery.

Figure 3

(A) Blood vessel through the brain parenchyma. (B) Cross-section of the blood vessel and the barriers a molecule would encounter crossing from the bloodstream into the brain parenchyma. A molecule would have to pass through the endothelial cell tight junctions or undergo transport across the endothelial cells themselves. Next the molecule would encounter the basal lamina and astrocytic endfeet.