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. 2015 Jul 16;11:1723–1737. doi: 10.2147/NDT.S84266

Figure 2.

Figure 2

Schematic Illustration of structural and functional regions of APOE.

Notes: (A) Location and structure of the APOE gene on chromosome 19. (B) APOE protein is a polypeptide chain with 299 amino acids consisting of a receptor-binding region (residues 136–150) in the N-terminal domain (residues 1–167) and a lipid-binding region (residues 244–272) in the C-terminal domain (residues 206–299). (C) Three major APOE isoforms are located at residues 112 and 158 (red circles), where APOE2 has Cys residues at both positions, APOE3 has a Cys residue at 112 and an Arg residue at 158, and APOE4 has Arg residues at both positions.

Abbreviation: APOE, apolipoprotein E.