Figure 7.

HE staining of bone tissue lesion (×100).

Notes: (A) Four weeks after the induction of chronic osteomyelitis, there was clearly visible inflammatory cell infiltration, fibrous hyperplasia, dead bone from periosteum to bone marrow cavity. (B–D) Treatment of osteomyelitis for 12 weeks. (B) In the drug-loaded group, the new bone and cartilage formed and materials were largely absorbed. (C) and (D), no drug-loaded group and blank group, respectively, inflammatory cells, fibrous hyperplasia, and dead bone were clearly visible, and new bone did not form. Long white arrow, inflammatory cells; short white arrow, bleeding; long black arrow, trabecular bone; short black arrow, dead bone; long red arrow, cartilage and chondrocytes; short red arrow, materials long green arrow, fibrous hyperplasia and necrosis; short green arrow, the tissue of medullary cavity.

Abbreviation: HE, hematoxylin and eosin.