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Elastic tissue after skin microneedling treatment. Skin samples at baseline, after one month and three months post-treatment were immunostained for total elastin (top row) showing a decrease in total elastin level. Immunofluorescence staining of tropoelastin (bottom row) shows increased deposition of newly synthesized tropoelastin in the dermis (IP “1st row” and IF “2nd row” staining; x200)
