TABLE 2.
Quantitative analysis of epidermal thickness and extracellular matrix proteins before and after microneedling treatment for post-acne atrophic scars
| (n=10) | (MEAN ± SD) | P-VALUE | ||||
|---|---|---|---|---|---|---|
| BASELINE | AFTER 1 MONTH OF TREATMENT (AFTER 2 SESSIONS) | AFTER 3 MONTHS POST-TREATMENT (AFTER 6 SESSIONS) | BASELINE VS. 1 MONTH OF TREATMENT | 1 MONTH OF TREATMENT VS. 3 MONTHS AFTER STARTING TREATMENT | BASELINE VS. 3 MONTHS AFTER STARTING TREATMENT | |
| Epidermal thickness (µm) | 63 ±4.9 | 72 ±7.1 | 80.2 ±3.8 | 0.01* | 0.02* | 0.004* |
| Collagen I (%) | 67.1 ±4.2 | 70.4 ± 5.4 | 78.2 ±6.8 | 0.175 | 0.03* | 0.01* |
| Collagen III (%) | 61.4 ±3.6 | 65.5 ±6.1 | 74.3 ± 7.4 | 0.07 | 0.02* | 0.01* |
| Collagen VII (%) | 15.2 ± 2.1 | 16.4 ±1.7 | 21.3 ±1.2 | 0.431 | 0.04* | 0.03* |
| Newly synthesized collagen (%) | 14.5 ±5.8 | 15.8 ±5.3 | 19.5 ±3.2 | 0.379 | 0.03* | 0.02* |
| Total elastin (%) | 51.3 ±6.7 | 50.1 ±4.7 | 46.9 ±4.3 | 0.492 | 0.05* | 0.04* |
| Tropoelastin (%) | 13.6 ±3.5 | 14.8 ±2.9 | 18.2 ±2.1 | 0.412 | 0.03* | 0.02* |
*
p<0.05