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. 2015 Apr 11;1(4):201–205. doi: 10.1016/j.hrcr.2015.02.011

Figure 3.

Figure 3

In silico effect of mutations on action potential duration (APD). A: Family tree of affected long QT (LQT) lineage. QTc at screening is indicated in seconds. Shading denotes the long QT syndrome (LQTS)–diagnosed proband carrying all 3 mutations. B: Predicted effect of family mutation status on APD. C: Isolating the effect of hERG-S654G and both hERG mutations from the proband’s simulated action potential shows all but approximately 15 ms of the prolongation is attributable to hERG-S654G and hERG-A913V together.