Table 4.

Boundaries of the validated regions with significant additive effects on milk yield and the most significant SNPs within the identified regions with their associated genes in discovery and validation populations

		Most strongly associated SNP in discovery						Most strongly associated SNP in validation
BTCa	Interval (Mbp)b	SNP	Position (bp)	-log10 (P)	Effect ± SE	MAFc	$\frac{{\sigma }_a^2}{{\sigma }_p^2}$ (%)d	SNP	Position (bp)	Effect ± SE	-log10 (P)	MAF	$\frac{{\sigma }_a^2}{{\sigma }_p^2}$ (%)	Genese
5	94.453 - 95.026	rs136374794	94518850	11.633	120.3 ± 17.11	0.300	0.490	rs136816685	95001236	−80.76 ± 16.46	6.013	0.471	0.459	PTPRO
5	96.927 - 97.854	rs110729080	97435197	8.791	149.8 ± 24.79	0.117	0.373	rs134869818	97031962	97.04 ± 16.57	8.291	0.452	0.660	GPRC5Af
14	1.428 - 5.289	rs109421300	1801116	134.354	−389.4 ± 15.34	0.369	5.694	rs109421300	1801116	−234.1 ± 17.53	38.947	0.468	3.858	DGAT1 f
20	29.568 - 30.367	rs134175348	30001269	7.230	−104.6 ± 19.27	0.206	0.289	rs42276093	29568029	−133.9 ± 19.25	11.382	0.270	0.999	NA

^aBTC: Bos Taurus chromosome

^bIntervals containing individually validated SNPs are in bold

^c MAF minor allele frequency

^d σ ²_a = additive variance; σ ²_p = phenotypic variance

^eGenes with both top SNPs in discovery and validation inside them are in bold

^fGenes with individually validated SNPs within them