Table 6.

Boundaries of the validated regions with significant dominance effect on milk yield as well as the most significant SNPs and their associated genes within these regions in discovery and validation populations^a

		Most strongly associated SNP in discovery						Most strongly associated SNP in validation
BTCa	Interval (Mbp)b	SNP	Position (bp)	-log10 (P)	Effect ± SE	MAFc	$\frac{{\sigma }_d^2}{{\sigma }_p^2}$ (%)d	SNP	Position (bp)	-log10 (P)	Effect ± SE	MAF	$\frac{{\sigma }_d^2}{{\sigma }_p^2}$ (%)	Genese
2	95.312 - 95.730	rs136022579	95312328	4.920	155 ± 35.39	0.166	0.149	rs134324850	95725812	3.563	132 ± 36.23	0.171	0.197	ADAM23
3	97.907 - 98.799	rs43361287	98306933	4.351	82.29 ± 20.14	0.443	0.133	rs43363311	97907057	2.516	64.04 ± 21.6	0.427	0.139	AGBL4
5	71.878 - 71.878	rs110106971	71878168	4.947	−99.82 ± 22.71	0.332	0.158	rs110106971	71878168	2.012	55.58 ± 21.49	0.438	0.106	SYN3 f
26	32.249 - 32.341	rs42460360	32248251	4.185	129.5 ± 32.42	0.186	0.124	rs42741343	32336734	2.065	61.42 ± 23.36	0.349	0.110	LOC100847832
26	39.358 - 39.765	rs132810457	39358269	4.017	86.38 ± 22.13	0.343	0.122	rs110552548	39764774	2.239	−88.38 ± 32	0.214	0.125	GRK5
26	44.215 - 44.543	rs109406756	44537471	4.673	114.1 ± 26.83	0.244	0.143	rs134524557	44257893	2.246	70.3 ± 25.4	0.301	0.123	LHPP
27	42.674 - 42.890	rs41665573	42837186	5.248	−90.48 ± 19.92	0.469	0.164	rs41575082	42673983	2.328	62.09 ± 21.95	0.424	0.130	NA

^aBTC: Bos Taurus chromosome

^bIntervals containing individually validated SNPs are in bold

^cMAF: minor allele frequency

^d σ ²_d = dominance variance; σ ²_p = phenotypic variance

^eGenes with both top SNPs in discovery and validation inside them are in bold

^fGenes with individually validated SNPs within them