Table 7.

Boundaries of the validated regions with significant dominance effect on calving interval and the most significant SNPs with their associated genes within these regions in discovery and validation populations

		Most strongly associated SNP in discovery						Most strongly associated SNP in validation
BTCa	Interval (Mbp)b	SNP	Position (bp)	-log10 (P)	Effect ± SE	MAFc	$\frac{{\sigma }_d^2}{{\sigma }_p^2}$ (%)d	SNP	Position (bp)	-log10 (P)	Effect ± SE	MAF	$\frac{{\sigma }_d^2}{{\sigma }_p^2}$ (%)	Genese
1	19.667 - 19.777	rs110080440	19706636	4.651	−3.802 ± 0.896	0.299	0.091	rs109600947	19776964	2.178	−4.129 ± 1.52	0.249	0.080	NA
2	80.202 - 80.654	rs41591067	80201648	4.412	3.07 ± 0.746	0.500	0.084	rs133868000	80276795	2.403	−3.268 ± 1.133	0.473	0.089	MYO1B f
3	15.808 - 15.963	rs134910746	15947344	4.119	3.024 ± 0.764	0.420	0.078	rs29020504	15808470	2.505	−5.434 ± 1.837	0.197	0.099	KCNN3
7	62.509 - 62.852	rs29013244	62508803	4.252	3.012 ± 0.747	0.480	0.081	rs43520270	62851917	2.123	3.664 ± 1.37	0.304	0.081	ABLIM3
23	46.082 - 46.581	rs137262994	46579868	4.494	−3.234 ± 0.777	0.407	0.087	rs109881533	46081778	2.401	4.222 ± 1.464	0.264	0.090	OFCC1
23	50.929 - 51.326	rs110165999	51326222	5.087	−5.153 ± 1.154	0.205	0.101	rs134147379	51081072	2.212	−3.689 ± 1.345	0.309	0.083	GMDS
25	39.070 - 39.921	rs135893130	39548382	4.364	−3.225 ± 0.788	0.390	0.084	rs108968775	39070284	2.808	3.583 ± 1.131	0.489	0.108	LOC618542
28	43.832 - 44.145	rs133899460	44144815	4.032	−2.918 ± 0.7461	0.480	0.076	rs109392728	43831664	2.404	−6.638 ± 2.302	0.143	0.089	CHAT

^a BTC Bos Taurus chromosome

^bIntervals containing individually validated SNPs are in bold

^c MAF minor allele frequency

^d σ ²_d = dominance variance; σ ²_p = phenotypic variance

^eGenes with both top SNPs in discovery and validation inside them are in bold

^fGenes with individually validated SNPs within them