Table 1.

Formula for calculating three estimators (F_GRM, F_HOM and F_UNI) for each genotype (homozygous for reference allele; heterozygous for reference and non-reference allele; homozygous for non-reference allele)

	FGRM	FHOM	FUNI
x i = 0	${\mathrm{F}}_{\mathrm{G}\mathrm{R}\mathrm{M}}=\frac{3p_i-1}{1-p_i}$	FHOM = 1	${\mathrm{F}}_{\mathrm{U}\mathrm{N}\mathrm{I}}=\frac{p_i}{1-p_i}$
x i = 1	${\mathrm{F}}_{\mathrm{G}\mathrm{R}\mathrm{M}}=\frac{6{p_i}^2-6p_i+1}{2p_i\left(1-p_i\right)}$	${\mathrm{F}}_{\mathrm{H}\mathrm{O}\mathrm{M}}=1-\frac{1}{2p_i\left(1-p_i\right)}$	FUNI = −1
x i = 2	${\mathrm{F}}_{\mathrm{G}\mathrm{R}\mathrm{M}}=\frac{2-3p_i}{p_i}$	FHOM = 1	${\mathrm{F}}_{\mathrm{U}\mathrm{N}\mathrm{I}}=\frac{1-p_i}{p_i}$

x _i is the number of reference allele