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. Author manuscript; available in PMC: 2016 Jun 8.
Published in final edited form as: Dev Cell. 2015 May 28;33(5):507–521. doi: 10.1016/j.devcel.2015.04.021

Figure 1. Bioinformatics prediction of transcription factors that regulate fetal cardiomyocyte proliferation.

Figure 1

A) Based on common expression trends, transcripts differentially expressed in cardiac development or adult remodeling (physiological and/or pathological) were grouped into 9 distinct clusters. Enriched Gene Ontology (GO) terms revealed biological processes associated with each cluster. Cluster 1 contained genes associated with cell cycle, strongly expressed in development and attenuated perinatally. B) Analysis for enrichment of evolutionarily conserved TF binding sites within the proximal promoters of all Cluster 1 genes, revealing candidate TF regulators of fCM proliferation. See also Table S1.