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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Pharm Res. 2014 Dec 24;32(7):2217–2228. doi: 10.1007/s11095-014-1610-1

Table 4.

The hydrogen bond lifetime τHB of hydrogen bonds between trehalose and phosphate at 310 and 510 K, respectively. (β=150°)

R τHB (ps) at 310 K τHB (ps) at 510 K

Tre-HPO42− Tre-H2PO4 Tre-HPO442− Tre-H2PO4
0.125 5.920 3.678 1.586 1.018
0.296 6.742 3.198 1.631 1.003
0.579 6.819 4.225 1.573 0.966
1.0 6.601 4.351 1.531 1.044