Table 4. Relative mean bias percentage, RMSE and coverage probability when N = 30000, m = 30, β 1 = 0.1, β 2 = 0.2, ρ b = 0.6, ρ w = 0.3.
Summary | Effects | Heterogeneity | Correlation | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
data | % Bias | RMSE b | Coverage | % Bias | RMSE b | % Bias | %( | |||||||||
Method | scenario | I 2, a | () | -1 | +1 | |1| | ||||||||||
MV | COM | 50% | 0 | 0 | 0 | 0 | 95.1 | 95.2 | 0 | 3 | 0 | 0 | 1 | 0.7 | 9.4 | 10.1 |
UV | COM | 0 | 0 | 0 | 0 | 95.1 | 95.3 | 0 | 3 | 0 | 0 | — | — | — | — | |
MV | COM c | 0 | 0 | 0 | 0 | 95.3 | 95.4 | 6 | 6 | 0 | 0 | 40 | 0.1 | 39.5 | 39.6 | |
MV | MAR | 0 | 0 | 0 | -2 | 95.1 | 94.8 | 0 | 3 | 0 | 0 | -2 | 1.9 | 16.3 | 18.2 | |
UV | MAR | 0 | 0 | 0 | 0 | 95.1 | 95.3 | 0 | 3 | 0 | 0 | — | — | — | — | |
MV | MIF | 0 | 27 | 0 | -12 | 95.2 | 57.8 | 0 | -31 | 0 | -4 | -9 | 6.4 | 26.8 | 33.2 | |
UV | MIF | 0 | 32 | 0 | 0 | 95.1 | 49.7 | 0 | -33 | 0 | 0 | — | — | — | — | |
MV | COM | 75% | 0 | 0 | 0 | 0 | 94.8 | 94.5 | 1 | 0 | 0 | 0 | -2 | 0 | 0.1 | 0.1 |
UV | COM | 0 | 0 | 0 | 0 | 94.9 | 94.4 | 1 | 0 | 0 | 0 | — | — | — | — | |
MV | COM c | 0 | 0 | 0 | 0 | 94.9 | 94.4 | 1 | 1 | 0 | 0 | 15 | 0 | 1.7 | 1.7 | |
MV | MAR | 0 | 0 | 0 | -3 | 94.8 | 94.1 | 1 | 1 | 0 | 2 | -2 | 0 | 0.7 | 0.7 | |
UV | MAR | 0 | 0 | 0 | 0 | 94.9 | 94.5 | 1 | 1 | 0 | 0 | — | — | — | — | |
MV | MIF | 0 | 26 | 0 | -16 | 94.8 | 76.1 | 1 | 6 | 0 | -4 | -1 | 0.1 | 1 | 1.1 | |
UV | MIF | 0 | 36 | 0 | 0 | 94.9 | 69.9 | 1 | 6 | 0 | 0 | — | — | — | — |
Abbreviation: RMSE, root mean square error; CI, confidence interval; MV, multivariate meta-analysis; UV, Univariate meta-analysis; COM, complete data scenario; MAR, end point 2 missing at random for 30% studies; MAR, end point 2 missing informatively for 30% studies.
aThe between-study variances for both end-points are: = 0.0036 for I 2 = 50%, = 0.0109 for I 2 = 75%.
bRMSE of estimates by MV method are expressed as % smaller (-) or larger (+) of corresponding estimates by UV method.
c ignored.