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. 2015 Jul 22;14:92. doi: 10.1186/s12933-015-0256-6

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© Waddingham et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Myosin mass transfer changes across the cardiac cycle. Mean intensity ratio (I_1,0/I_1,1) at end diastole (ED, a) and systolic minimum (b) in the epicardial, subepicardial and subendocardial layers of the left ventricle. Intensity ratio did not significantly differ between vehicle-treated control and diabetic rats or fasudil-treated (10 mg/kg/day) control and diabetic rats in the epicardium or subepicardium at either time point. In the deep subendocardial layer, diabetic rats had a significantly elevated ED and systolic minimum intensity ratio (P < 0.05). Data expressed as mean ± SEM. *P < 0.05 vs. control in the same myocardial layer. N = 4–6 per group.