Table 2.
Load dependent indices of left ventricular function as measured by pressure–volumetry from Experiment 1
| Control | Diabetic | Diabetic + fasudil | |
|---|---|---|---|
| Heart rate (BPM) | 350 ± 12 | 290 ± 12** | 299 ± 13** |
| End systolic pressure (mmHg) | 127 ± 6 | 95 ± 9** | 115 ± 5 |
| End diastolic pressure (mmHg) | 7.5 ± 0.9 | 7.8 ± 1 | 8.7 ± 1 |
| Stroke volume (μl) | 168 ± 20 | 184 ± 8 | 193 ± 17 |
| Cardiac output (ml/min) | 59.4 ± 8.1 | 53.5 ± 3.5 | 57.7 ± 5.6 |
| Ejection fraction (%) | 66 ± 8 | 60 ± 7 | 50 ± 3 |
| dP/dtmaximum (mmHg/s) | 7,391 ± 602 | 6,616 ± 470 | 7,096 ± 641 |
| dP/dtminimum (mmHg/s) | −8,210 ± 632 | −5,917 ± 502* | −6,439 ± 569* |
| Tau Glantz (ms) | 12 ± 0.3 | 14.4 ± 0.7* | 14.2 ± 0.8* |
Data expressed as mean ± SEM.
dP/dtmaximum, maximum rate of left ventricular pressure development; dP/dtminimum, minimum rate of left ventricular pressure decay.
* P < 0.05 and ** P < 0.01 vs. control rats.