Table 3.
Association of Patient Characteristics With Native T1 (ms) in Remote Myocardium in Univariable and Multivariable Stepwise Regression Analyses (n = 288)
| Multiple Stepwise Regression | Coefficient (95% CI) | p Value |
|---|---|---|
| Including patient characteristics and angiographic data | ||
| Male | −9.93 (−16.23 to −3.62) | 0.002 |
| Previous MI | 11.38 (1.10 to 21.67) | 0.030 |
| Killip class IV | 28.64 (1.00 to 56.28) | 0.042 |
| No ST-segment resolution | 12.05 (3.67 to 20.43) | 0.005 |
| Incomplete ST-segment resolution | 9.30 (3.20 to 15.39) | 0.003 |
| Including patient characteristics, angiographic data, and CRP | ||
| Male | −9.54 (−16.62 to −2.47) | 0.008 |
| No ST-segment resolution | 10.54 (1.11 to 19.97) | 0.029 |
| Incomplete ST-segment resolution | 9.46 (2.41 to 16.50) | 0.009 |
| Log initial CRP | 2.75 (−0.09 to 5.58) | 0.057 |
| Including patient characteristics, angiographic data, initial CRP, and LV end-diastolic volume | ||
| Male | −12.74 (−20.69 to −4.79) | 0.002 |
| BMI, kg/m2 | −0.63 (−1.33 to 0.08) | 0.083 |
| No ST-segment resolution | 10.12 (0.69 to 19.56) | 0.036 |
| Incomplete ST-segment resolution | 9.42 (2.37 to 16.47) | 0.009 |
| Log initial CRP | 3.01 (0.016 to 5.85) | 0.038 |
| LV end-diastolic volume | 0.10 (−0.01 to 0.21) | 0.084 |
| Including patient characteristics, angiographic data, peak monocyte count, and LV end-diastolic volume | ||
| Male | −14.31 (−22.33 to −6.29) | <0.001 |
| Previous myocardial infarction | −0.63 (−1.33 to 0.08) | 0.083 |
| No ST-segment resolution | 10.09 (0.72 to 19.47) | 0.035 |
| Incomplete ST-segment resolution | 9.23 (2.29 to 16.17) | 0.009 |
| Peak monocyte count, × 109/l | 10.20 (0.74 to 19.67) | 0.035 |
| LV end-diastolic volume | 0.10 (−0.01 to 0.21) | 0.088 |
The coefficient (95% CI) indicates the magnitude and direction of the difference in remote zone T1 (ms) for the patient characteristic (binary or continuous). For example, on average, remote zone native T1 (ms) 2 days post-MI was −9.93 (95% CI: −16.23 to −3.62) lower for male versus female, and native T1 (ms) was 0.14 (95% CI: 0.01 to 0.26) higher for each 1-ml increase in LV end-systolic volume. Previous MI affecting a territory of remote myocardium could alter native T1, which could be a confounding factor in the multivariable analysis of associates of remote zone native T1. In a sensitivity analysis involving backward stepwise variable selection, removing previous MI had no effect on the results of the multivariable models.