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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: J Thorac Oncol. 2014 Apr;9(4):456–463. doi: 10.1097/JTO.0000000000000130

Figure 2.

Figure 2

Pedigree of family with germline T790M mutation. Age, smoking history, mutation status and other cancer history are recorded.

*In addition to the three obligate carriers identified in the pedigree, either individual I:1 or I:2 is a obligate carrier based on pedigree analysis. Individual III:3 is reported to have died from bladder cancer. She had lung cancer, but it is uncertain if this was a primary cancer or a metastasis. She was not considered to be a lung cancer case. Individual V:1 had a lung carcinoid tumor. There are two never smokers that developed lung cancer in the family (II:2 and III:6), given the low likelihood that they represent two sporadic cases in this family we have assumed that they are also mutation carriers, thus for a total of 14 known, obligate or assumed mutation carriers. There are two never smokers that developed lung cancer in the family (II:2 and III:6), given the low likelihood that they represent two sporadic cases in this family we have assumed that they are also mutation carriers, thus for a total of 14 known, obligate or assumed mutation carriers.