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. 2015 Jul 21;10(7):e0133619. doi: 10.1371/journal.pone.0133619

Fig 4. Genetic overexpression of ATX from the bronchial epithelium has minor effects in ALI development.

Fig 4

Transgenic (TgCC10hEnpp2 +/+) mice overexpressing hATX in the bronchial epithelium and littermate wild type mice were administered aerosolized LPS to induce ALI and were sacrificed 24 hours later (n = 3–10; a representative experiment out of two is shown). A-C. Histological analysis (A) and BALF measurements (B & C) indicated no significant changes in the lungs of mice overexpressing ATX expression in the bronchial epithelium in comparison to their wild type littermates. D. Increased enzyme activity of ATX in the transgenic mice.