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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: Mol Cell. 2010 Sep 24;39(6):963–974. doi: 10.1016/j.molcel.2010.08.029

Figure 4. MAGE-G1-NSE1 Crystal Structure.

Figure 4

(A) Crystal structure of MAGE-G1-NSE1 complex. MAGE-G1 MHD forms a tandem winged helix (WH-A, purple; WH-B, cyan). The two zinc ions coordinated by the NSE1 RING domain are shown as gray spheres.

(B) Crystal structure of the MAGE-A4 MAGE homology domain (PDB: 2WA0) consisting of two winged helix motifs (WH-A, yellow-green; WH-B, cream).

(C) Orientation of MAGE WH-A to WH-B differs between MAGE-G1 and MAGE-A4. (Left) MAGE-A4 aligned to MAGE-G1-NSE1 based on WH-A motif. (Right) MAGE-A4 WH-B aligns with MAGE-G1 WH-B after rotation, as indicated by the arrow.