Table 3.
Proportion and adjusted odds ratio of positive remodeling by HIV and plaque characteristics among atherosclerotic artery segments
| n with PR (n=114) | n with plaque (n=2034) | % with PRa | Adjusted Odds Ratiob | (95% CI) | |
|---|---|---|---|---|---|
| HIV Infection | |||||
| No | 34 | 799 | 4.3% | 1 [reference] | |
| Yes | 80 | 1235 | 6.5% | 1.52 | (0.79,2.95) |
| Plaque type and stenosis interactions | |||||
| Calcified plaque (with or without stenosis) | 11 | 655 | 1.7% | 1 [reference] | |
| Non-calcified plaque without stenosis | 48 | 861 | 5.6% | 4.16*** | (1.81, 9.55) |
| Mixed plaque without stenosis | 27 | 344 | 7.8% | 6.32*** | (2.62, 15.24) |
| Non-calcified plaque with stenosis | 12 | 80 | 15% | 11.87***,† | (4.09, 34.48) |
| Mixed plaque with stenosis | 16 | 94 | 17% | 12.51*** | (4.45, 35.14) |
CI=Confidence Interval. PR=Positive Remodeling.
*
p < 0.05,
**
p < 0.01,
***
p < 0.001.
†
The association between non-calcified plaque and PR is statistically significantly greater when the segment also has a stenosis >50%, p=0.02.
a
Observed proportion at the segment-level, not adjusted for clustering within individuals.
b
Adjusted odds ratios for each variable are reported from the same model that includes age, race, and coronary artery disease risk factors, and that accounts for clustering within individuals. N=1959 segments with non-missing covariates included in the adjusted analysis.