Table 3.

Association between esophageal eosinophilia and CD with increasingly restrictive definitions of EoE

EoE definition	(n)	EoE with CD on biopsy (n)	OR (95% CI)	aOR** (95% CI)
No EoE	84,416	1,131	Referent	Referent
EoE as defined by:
≥15 eos/hpf	4,101	72	1.32 (1.04, 1.67)	1.26 (0.98, 1.60)
≥15 eos/hpf and dysphagia	1,406	23	1.23 (0.81, 1.86)	1.18 (0.78, 1.80)
≥15 eos/hpf, eosinophilic microabscesses, and exclusion of competing conditions*	230	4	1.30 (0.49, 3.51)	1.25 (0.46, 3.37)
≥50 eos/hpf)	1,050	23	1.65 (1.09, 2.50)	1.58 (1.04, 2.41)
≥100 eos/hpf)	227	5	1.66 (0.68, 4.03)	1.57 (0.64, 3.82)

^*Competing conditions included reflux/heartburn symptoms, RE, BE, IBD, and eosinophilic gastroenteritis

^**Adjusted for age, sex