Fig. 1.

CCL2 concentrations presented with a log scale to illustrate the magnitude of increased CCL2 relative to the other cytokines examined. An increase of 3–7 times the basal levels was observed 2 h after SE, 10–25 times the control levels 6 h after SE, and reached a peak 24 h after SE in the hippocampus, piriform cortex, and neocortex with increases of ~100-, ~200-, and ~250-fold, respectively. Five days after seizures, CCL2 concentration was still significantly elevated in the piriform cortex, hippocampus, and neocortex (*p < 0.001 in all cases). No significant alterations to CCL2 concentrations were observed in the cerebellum