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. Author manuscript; available in PMC: 2016 Aug 1.
Published in final edited form as: Am J Hematol. 2015 May 28;90(8):702–708. doi: 10.1002/ajh.24046

Figure 2. Comparison of serum immunoglobulins and lymphocyte subsets in patients with relatives.

Figure 2

● Children; x Adults. Adjusted mean (adjusted for age, sex, treatment with corticosteroids, and severe bone marrow failure) and 95% confidence intervals are shown. Group comparisons are between children (<18 year old) with each syndrome and combined pediatric relatives, and between adult patients (≥18 years) with syndromes and combined adult relatives. *Significant (p<0.05). A) IgG levels were low in adults with FA (p<0.0001) and children and adults with DBA and SDS (p<0.001) compared with patients with other syndromes and relatives within the same age range. B) IgA levels were lower in adults with FA and higher in adults with DC (p<0.0001). C) All children had lower IgM than all adults (p=0.03). Children with FA, DBA and SDS had low IgM, as did adults with FA compared with relatives within the same age groups (p=0.0001). D) Absolute lymphocyte counts (ALCs) were low in adults with FA and in children and adults with DC (p<0.001). E and F) Adults with FA and children and adults with DC had low CD3 and CD4+/CD3+ T cells (p<0.001). G) Children with DC and DBA had low CD8+/CD3+ T cells (p=0.005). H) Children and adults with FA and children with DC had low CD19+ B cells (p<0.001). I) Children with all four syndromes as well as adults with FA had low NK cells (p=0.004).