Table 4. Tests for gender differences of KLOTHO methylation and important parameters.

	case				control
	Han	Uygur	p value	adjusted p value (by age)	Han	Uygur	p value	adjusted p value (by age)
male
BMI	25.34±2.82	24.96±4.32	0.721		24.15±2.37	23.72±3.53	0.625
Age(years)	78.33±6.31	72.00±4.50	3.60E-04		78.71±6.27	72.46±4.46	2.44E-04
CpG1	10(7,11.75)	6(6,7)	4.11E-04	0.009	6(6,7)	7(6,7)	0.897	0.888
CpG2	3(3,4)	2(2,3)	0.003	0.047	2(2,2)	2(2,2)	0.291	0.533
CpG3	3(3,4)	2(1,2)	3.73E-04	0.009	2(2,3)	2(2,2)	0.388	0.756
CpG4	7.5(5,8)	5(5,5)	0.012	0.121	5(4,5)	5(5,6)	0.215	0.729
CpG5	6(4,7)	3(3,4)	4.03E-04	0.034	4(3,5)	3(3,4)	0.920	0.936
female
BMI	23.64±2.52	22.21±2.53	0.057		24.85±4.11	22.53±4.69	0.075
Age(years)	76.50±4.54	69.67±3.81	9.88E-07		76.71±4.60	69.58±3.98	7.11E-07
CpG1	9.5(6,11.75)	6.5(6,7)	0.010	0.012	6(5.25,7)	6(6,7)	0.871	0.778
CpG2	3(2,4)	2(2,3)	0.016	0.215	2(2,2)	2(2,2)	0.692	0.181
CpG3	3(2,4)	2(2,2)	0.001	0.105	2(2,2)	2(1,2)	0.128	0.39
CpG4	8(5,8)	5(5,5)	0.003	0.017	5(5,5)	5(4,5)	0.973	0.897
CpG5	7(4,8)	4(3,4)	0.001	0.006	4(3,4)	3(3,4)	0.510	0.645