Figure 1.

Pedigrees of control and mutator mice in a long-term breeding study. All breeding lines that were separated by five or more generations from the original line are shown: blue, wild-type; black, surviving mutator lines; and red, extinct mutator lines. Green arrows indicate whole-genome sequencing was performed on mice from the indicated generations. The first appearance of a conspicuous phenotypic anomaly is shown for each breeding line. Gray shading indicates body weight was analyzed for the generations indicated (see Fig. 3, legend).