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. 2015 Aug;25(8):1125–1134. doi: 10.1101/gr.186148.114

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© 2015 Uchimura et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Reduced mutator mouse reproduction. (A) Live offspring per mating, plotted against the number of generations; red, mutator mice; blue, control; dots, individual mice; circles, mean for the generation. Solid lines show linear fit and dashed lines show the 95% CI, assuming a negative binomial distribution; green line, regression curve using the recessive lethal mutation model for the mutator lines. (B) The Itga8-mutant genotype in mutD; squares, males; circles, females; filled, homozygotes (but not present here); half-filled, heterozygotes; empty, no Itga8 mutation; and dashed-line circles, post-natal deaths. (×) Failure to reproduce. In 26 tested offspring obtained from the heterozygous intercross, there were no homozygotes (6.5 homozygotes would be expected for a neutral mutation, χ²-test; P < 0.01), indicating that this mutation had a recessive lethal effect on the phenotype.