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Representative serial sections from 2 typical anti-HMGCR myopathy patients (A,B and C,D) show significant staining for M2 macrophages with anti-CD163 (A,C) but no M1 macrophages staining positive for CD11c (B,D). In contrast, sections from a single patient who was later diagnosed with cholangiocarcinoma had a modestly increased number of CD11c positive M1 macrophages (F,H) in addition to large numbers of M2 macrophages which stain positively for CD163 (E,G).
