Table 4.
Histological comparison between the control and the Botroclot site on day 14
| Histological parameters | Control (n = 20) score | Botroclot (n = 19) score | z-value | p value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | |||
| Epithelium type | – | 1 (5 %) | 18 (90 %) | 1 (5 %) | – | – | – | 10 (52.6 %) | 9 (47.4 %) | – | −2.496 | 0.013 |
| Collagen quantity | – | 9 (45 %) | 11 (55 %) | – | – | – | 1 (5.3 %) | 14 (73.7 %) | 4 (21.1 %) | – | −3.051 | 0.002 |
| Collagen organization | – | – | 12 (60 %) | – | 8 (40 %) | – | – | 5 (26.3 %) | – | 14 (73.7 %) | −2.449 | 0.014 |
| Fibroblast activity | – | 15 (75 %) | 5 (25 %) | – | – | – | 7 (36.8 %) | 10 (52.6 %) | 2 (10.5 %) | – | −2.179 | 0.029 |
| Inflammation | – | 3 (15 %) | 16 (80 %) | 1 (5 %) | – | – | 1 (5.3 %) | 12 (63.2 %) | 6 (31.6 %) | – | −2.449 | 0.014 |
| Inflammatory cells | – | – | 4 (20 %) | 16 (80 %) | – | – | – | 9 (47.4 %) | 10 (52.6 %) | – | −1.732 | 0.083 |
| Degree of fibrosis | – | 9 (45 %) | 11 (55 %) | – | – | – | 2 (10.5 %) | 16 (84.2 %) | 1 (5.3 %) | – | −2.121 | 0.034 |
| Presence of fibrin mesh | 2 (10 %) | 5 (25 %) | 10 (50 %) | 3 (15 %) | – | – | 1 (5.3 %) | 12 (63.2 %) | 6 (31.6 %) | – | −2.066 | 0.039 |
p value ≤ 0.05 is significant