Table 5.
Histological comparison between the control and the botroclot site combined on day 7 and day 14
| Histological parameters | Control (n = 36) score | Botroclot (n = 37) score | z-value | p value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | |||
| Epithelium | – | 7 (19.4 %) | 28 (77.8 %) | 1 (2.8) | – | – | 2 (5.4 %) | 24 (64.9 %) | 11 (29.7 %) | – | −3.120 | 0.002 |
| Collagen quantity | 1 (2.8 %) | 22 (61.1 %) | 13 (36.1 %) | – | – | 1 (2.7 %) | 11 (29.7 %) | 21 (56.8 %) | 4 (10.8 %) | – | −2.688 | 0.007 |
| Collagen organization | 1 (2.8 %) | – | 25 (69.4 %) | – | 10 (27.8 %) | 1 (2.7 %) | – | 15 (40.5 %) | – | 21 (56.8 %) | −3.000 | 0.003 |
| Fibroblast activity | – | 25 (69.4 %) | 11 (30.6 %) | – | – | – | 22 (59.5 %) | 12 (32.4 %) | 3 (8.1 %) | – | −1.355 | 0.175 |
| Inflammation | – | 9 (25 %) | 25 (69.4 %) | 2 (5.6 %) | – | – | 7 (18.9 %) | 20 (54.1 %) | 10 (27 %) | – | −2.138 | 0.33 |
| Inflammatory cells | – | 1 (2.8 %) | 17 (47.2 %) | 18 (50 %) | – | – | – | 26 (70.3 %) | 11 (29.7 %) | – | −1.604 | 0.109 |
| Degree of fibrosis | – | 15 (41.6 %) | 19 (52.8 %) | 2 (5.6 %) | – | – | 5 (13.5 %) | 25 (67.6 %) | 7 (18.9 %) | – | −2.082 | 0.037 |
| Presence of fibrin mesh | 9 (25 %) | 9 (25 %) | 13 (36.1 %) | 5 (13.9 %) | – | 5 (13.5 %) | 7 (18.9 %) | 19 (51.4 %) | 6 (16.2 %) | – | −1.576 | 0.115 |
| Presence of osteoid bone formation | – | – | – | – | – | – | – | 4 (10.81 %) | – | – | – | – |
p value ≤ 0.05 is significant