Table 4.
Conservation profile of amino acids in RNASEL that coincide in location with high-risk nsSNPs.
| rsIDs | Residue pos. | Residue | CS | Color | Buried or exposed | Function |
|---|---|---|---|---|---|---|
| rs151296858 | 59 | G | −0.834 | 8 | e | f |
| rs114166108 | 62 | P | −0.99 | 9 | e | f |
| rs182539049 | 184 | L | −0.296 | 6 | b | |
| rs138685180 | 224 | L | −0.146 | 6 | b | |
| rs145415894 | 276 | A | −1.202 | 9 | b | s |
| rs142939718 | 361 | L | −1.16 | 9 | b | s |
| rs35896902 | 592 | R | −0.915 | 8 | e | f |
| rs147890567 | 595 | T | −0.345 | 6 | b | |
| rs150721457 | 673 | I | −0.552 | 7 | b |
CS: conservation score (1–4 = variable, 5 = average, and 6–9 = conserved); (f): predicted functional site; (s): predicted structural site.