Table 7.
I-mutant predictions for selected nsSNPs.
| Mutation | Sign of DDG | DDG value prediction kcal/mol | RI | RSA |
|---|---|---|---|---|
| G59S | Decrease | −1.36 | 5 | 3.8 |
| P62S | Decrease | −2.15 | 8 | 0.7 |
| L184S | Decrease | −2.24 | 5 | 0.0 |
| L224P | Decrease | −2.13 | 9 | 15.8 |
| A276V | Increase | 0.66 | 3 | 0.9 |
| L361P | Decrease | −1.59 | 8 | 0.0 |
| R592H | Decrease | −0.99 | 9 | 6.6 |
| T595M | Decrease | −0.54 | 7 | 2.2 |
| I673T | Decrease | −2.46 | 9 | 9.2 |
DDG: free energy change value in Kcal/mol (>0 increase, <0 decrease, >0.5 large increase, and <2.5 large decrease); sign of DDG: the direction of the change (increase or decrease); the reliability index (RI) from 0 to 9 is shown in parentheses, where 0 is the lowest RI and 9 is the highest; RSA: relative surface accessibility.