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. 2015 Sep;59:59–70. doi: 10.1016/j.psyneuen.2015.05.003

Figure 2.

Figure 2

Anxiety-like and depressive-like behaviors in HSD2BKO mice compared to littermate controls (CON). (A) Exploration of the open arms of the Elevated-plus maze (EPM) did not differ between genotypes although restraint stress prior to testing did reduce exploration of the open arm (*p < 0.05, Two-way ANOVA F(1,63) = 6.07, n = 10–23). HSD2BKO exhibited increased depressive-like behavior in the B. Tail suspension test (TST; t-test t = 2.25) and (C) Novelty Induced hypophagia test (NIH; t-test t = 2.14), with a trend for the HSD2BKO mice to spend more time floating in the Forced swim test (FST; D). Values are mean ± SEM, n = 11 (CON) and 9 (HSD2BKO). *p < 0.05 compared to CON.