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. 2015 Sep;59:59–70. doi: 10.1016/j.psyneuen.2015.05.003

Figure 4.

Figure 4

Watermaze learning and hippocampal expression of 5-HT1A receptor mRNA in HSD2BKO and global 11β-HSD2 KO mice (11β-HSD2−/−). (A) During the watermaze training period there is a significant deficiency in performance on day 3 of training in the HSD2BKO compared to CON (^p < 0.05 compared to CON day 3; n = 7–8). (B) 11β-HSD2+/+ and +/− mice exhibit a significant improvement in performance of the task between day 1 and 2, whereas 11β-HSD2−/−, do not exhibit an improvement (n = 8–10). Hippocampal Htr1a mRNA expression in the CA1 field of HSD2BKO (C) and heterozygous-bred global knockouts of 11β-HSD2 (D) as assessed by in situ hybridisation histochemistry was significantly decreased in comparison to controls (CON: n = 5 vs. HSD2BKO: n = 6; *p < 0.05; 11β-HSD2+/+, 11β-HSD2+/− vs. 11β-HSD2−/−: n = 6 in all cases, *p < 0.05, one-way ANOVA). Values are mean ± SEM; n = 5–6.