Table 5.
Combination Drugs Filled by Persons with Depression or Anxiety/PTSD by 6-Month Interval
| Characteristic | 1 | 2 | 3 | 4 | 5 | 6 | 7 | Total |
|---|---|---|---|---|---|---|---|---|
| All subjects, N | 206,869 | 162,706 | 118,660 | 80,602 | 53,562 | 30,801 | 5080 | 658,280 |
| Subjects with depression, N (%) | 14,088 (6.8) | 15,456 (9.5) | 13,813 (11.6) | 10,657 (13.2) | 7941 (14.8) | 5331 (17.3) | 1182 (23.3) | 68,468 (10.4) |
| Opioids+Antidepressants, N (%)* | 9667 (68.6) | 6276 (40.6) | 5027 (36.4) | 3576 (33.6) | 2538 (32) | 1750 (32.8) | 482 (40.8) | 29,316 (42.8) |
| Opioids+Benzodiazepines, N (%)* | 6329 (44.9) | 4547 (29.4) | 3733 (27) | 2711 (25.4) | 1995 (25.1) | 1416 (26.6) | 431 (36.5) | 21,162 (30.9) |
| Opioids + zolpidem, N (%)* | 2818 (20.0) | 2010 (13.0) | 1659 (12.0) | 1248 (11.7) | 896 (11.3) | 645 (12.1) | 189 (16.0) | 9465 (13.8) |
| Opioids + Antidepressants+Benzodiazepines, N (%)* | 4856 (34.5) | 3319 (21.5) | 2640 (19.1) | 1899 (17.8) | 1368 (17.2) | 940 (17.6) | 286 (24.2) | 15,308 (22.4) |
| Opioids+Benzodiazepines+Zolpidem, N (%)* | 1677 (11.9) | 1232 (8.0) | 1007 (7.3) | 749 (7.0) | 515 (6.5) | 370 (6.9) | 108 (9.1) | 5658 (8.3) |
| Opioids +Antidepressants+Benzodiazepines+ Zolpidem, N (%)* | 1368 (9.7) | 956 (6.2) | 782 (5.7) | 591 (5.6) | 374 (4.7) | 266 (5.0) | 79 (6.7) | 4416 (6.5) |
| Subjects with anxiety/PTSD, N (%) | 15,532 (7.5) | 17,764 (10.9) | 16,274 (13.7) | 12,933 (16.1) | 9626 (18) | 6317 (20.5) | 1346 (26.5) | 79,792 (12.1) |
| Opioids+Antidepressants, N (%)† | 7766 (50) | 5204 (29.3) | 4298 (26.4) | 3127 (24.2) | 2265 (23.5) | 1542 (24.4) | 431 (32) | 24,633 (30.9) |
| Opioids+Benzodiazepines, N (%)† | 8715 (56.1) | 5970 (33.6) | 5007 (30.8) | 3671 (28.4) | 2663 (27.7) | 1810 (28.7) | 530 (39.4) | 28,366 (35.6) |
| Opioids + Zolpidem, N (%)* | 2770 (17.8) | 1976 (11.1) | 1708 (10.5) | 1306 (10.1) | 939 (9.8) | 646 (10.2) | 179 (13.3) | 9524 (11.9) |
| Opioids +Antidepressants +Benzodiazepines, N (%)† | 4922 (31.7) | 3295 (18.6) | 2685 (16.5) | 1947 (15.1) | 1414 (14.7) | 952 (15.1) | 289 (21.5) | 15,504 (19.4) |
| Opioids +Antidepressants+Benzodiazepines, N (%)† | 4922 (31.7) | 3295 (18.6) | 2685 (16.5) | 1947 (15.1) | 1414 (14.7) | 952 (15.1) | 289 (21.5) | 15,504 (19.4) |
| Opioids +Benzodiazepines+Zolpidem, N (%)† | 1938 (12.5) | 1390 (7.8) | 1161 (7.1) | 859 (6.6) | 602 (6.3) | 419 (6.6) | 116 (8.6) | 6485 (8.1) |
| Opioids +Antidepressants+Benzodiazepines + Zolpidem, N (%)† | 1270 (8.2) | 877 (4.9) | 732 (4.5) | 572 (4.4) | 357 (3.7) | 252 (4) | 70 (5.2) | 4130 (5.2) |
*Entries are N(%) among subjects with depression
†Entries are N(%) among subjects with anxiety/PTSD