Table 2. Analysis of prognostic factors for grade ≥2 stenosis after high dose rate brachytherapy.
Variable | No. | Grade ≥2 actual stenosis rate at 3 years (%) | p-value |
---|---|---|---|
Age (yr) | 0.480 | ||
<65 | 33 | 64 | |
≥65 | 24 | 57 | |
T stage | 0.870 | ||
T1 | 2 | 50 | |
T2 | 20 | 46 | |
≥ T3 | 35 | 40 | |
A factor (lower extension to vagina) | 0.140 | ||
T2a+T3a | 6 | 100 | |
Other | 51 | 58 | |
N stage | 0.110 | ||
N0 | 39 | 53 | |
N1 | 18 | 74 | |
Total prescribed dose (EQD2: α/β=3) | 0.970 | ||
<84 Gy | 24 | 52 | |
≥ 84 Gy | 33 | 66 | |
External beam RT dose (EQD2: α/β=3) | 0.660 | ||
<30 Gy | 48 | 61 | |
≥ 30 Gy | 9 | 49 (at 2 yr) | |
Brachytherapy dose (EQD2: α/β=3) | 0.550 | ||
<63 Gy | 33 | 48 | |
≥ 63 Gy | 24 | 81 | |
Modality | 0.180 | ||
Intracavitary | 42 | 72 | |
Interstitial | 15 | 39 | |
Chemotherapy | 0.450 | ||
Received | 27 | 56 | |
Not received | 30 | 61 | |
Pallor reaction at 6 months | 0.001 | ||
<Grade 2 | 47 | 53 | |
≥ Grade 2 | 10 | 100 |
EQD2, the biologically equivalent dose calculated into equivalent 2-Gy fractions; N, node; RT, radiotherapy; T, tumor.