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. 2015 Jul 21;10(7):e0132620. doi: 10.1371/journal.pone.0132620

Table 6. The comparison and outcome of Newcastle-Ottawa Scale.

Author Publication y Comparability of cohorts on the basis of the design or analysis a Assessment of outcome (a or b = 1) follow-up long enough (a = 1, b = 0) Adequacy of follow up of cohorts (a = 1, b = 0)
Harousseau 1997[55] NA b a b
Slovak 2000[6] NA b a a
Suciu 2003[5] Age, WBC count at diagnosis, FAB subtype, and the CR rate after the first induction coursec b a a
Tsimberidou 2003[56] Age b b a a
Brunett 2006[12,64] Age, Sex, Type of AML, WBC count, FAB type,Risk group, Status after course 1, Intermediate-risk, Adverse-risk, Unknown c Favorable-risk b b a a
Cornelissen 2007[11] Age, FAB type, WBC count, Number of cycles to achieve remission, Cytogenetic risk distributions prognostic risk score b b a a
Pfirrmann 2012[57] only described: age, sex, WBC count, disease status, cytogenetic risk profile at diagnosis, combined cytogenetic risk, disease status variable, FLT3-ITD mutant-to-wild-type ratio, NPM1 mutation status, CEBPA mutation status, peroxidase-positive blasts, CD34-positive blasts, Blasts in bone marrow after first cycle of induction b a b
Zhu 2013 d [58] Age, WBC count, BM blast c b a a
Stelljes 2014[59] Age, cytogenetic risk classification, sex, FAB type, WBC count, LDH, induction treatment c b a a

y indicates year; NA, not applicable; and WBC, white blood cell.

aFor most of the intermediate-risk are subgroup of the AML patients, there are no direct comparison between intermediate-risk group, so this item we just referred, not literally to the criteria

b P < 0.05

c P > 0.05

dcomparison of group among intermediate-risk AML patients, other comparison of AML patients.