Fig 4. Pharmacological sensitivity of I_cs.

A: Changes (as compared to break-in) in current amplitude at +40 mV in response to the potential I_cs antagonists: carbenoxelone (100 μM), SKF96365 (100 μM), 2-APB (100 μM), La³⁺ (1 mM) and TEA (40 mM). La³⁺ concentration was reduced to 100 μM when co-applied with TEA. B: Comparison of current amplitudes at +40 mV when recording electrodes contained either Cs⁺ (135 mM) or Cs⁺ + TEA (30 mM of TEA replaced) to block K⁺ channels. P values represent comparison to control, P > 0.05; *P < 0.05, **P < 0.01, ***P < 0.001). Data shown are averages and error bars represent s.e.m.