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Cp40 abrogates complement dysregulation induced by C4Nefs in vitro. (a) Illustration of C4Nef assay (C4Nefs, purple Y). Cp40 is introduced at time points as indicated by the diamonds. (b) Cp40 prevents formation of C5 convertase (C4b2a3b), thus inhibiting C4Nef-mediated complement dysregulation in patients who are C4Nef positive (n=3).
