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. Author manuscript; available in PMC: 2015 Jul 22.
Published in final edited form as: Microbiol Spectr. 2015 Jun;3(3):10.1128/microbiolspec.MBP-0016-2015. doi: 10.1128/microbiolspec.MBP-0016-2015

Figure 3. Diagram of central metabolism and map of the specific pathways disrupted by targeted mutations in uropathogenic E. coli.

Figure 3

Carbon sources or biochemical intermediates shared between pathways are indicated in capital letters or abbreviated: G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; G3P, glyceraldehyde-3-phosphate; 6PGN, 6-phosphogluconate. Reactions are denoted with arrows. Specific reactions (red arrows) were targeted by deletion or insertion in E. coli CFT073. In glycolysis: pgi, glucose-6-phosphate isomerase; pfkA, 6-phosphofructokinase transferase; tpiA, triosephosphate isomerase; pykA, pyruvate kinase; in pentose phosphate pathway: gnd, 6-phosphogluconate dehydrogenase; talB, transaldolase; in Entner-Duodoroff pathway: edd, 6-phosphogluconate dehydratase; in gluconeogenesis: pckA, phosphoenolpyruvate carboxykinase; and in the TCA cycle: sdhB, succinate dehydrogenase; fumC, fumarate hydratase; frdA, fumarate reductase. (From, Alteri, Christopher J., Stephanie Himpsl, and Harry L.T. Mobley. 2015. Preferential Use of Central Metabolism in vivo Reveals a Nutritional Basis for Polymicrobial Infection. PLoS Pathogens 11:e1004601.)