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The Notch signaling pathway depicted between two cells in the neocortical germinal zone. The ligand-expressing cell may be either a neuron or an intermediate progenitor, whereas the signal-receiving cell is inhibited from undergoing neuronal differentiation. (PS1/2) Presenilin 1 and 2, the catalytic subunits of the γ-secretase complex; (Mib1) mindbomb1; (Dtx) Deltex; (NICD) Notch intracellular domain; (MAML) Mastermind-like; (CBF1) C-promoter-binding factor 1.
