Table 1. Distribution of mutation patterns in rpoB, katG, and inhA among drug-resistant Mycobacterium tuberculosis isolates.
| Drug resistance | N and proportion of resistant gene | Mutation type | N (%) in MDR strains (n = 33) | N (%) in INH monoresistant strains (n = 10) |
|---|---|---|---|---|
| RIF (n = 33) | rpoB (33, 100%) | L511P | 1 (3.0) | - |
| D516V | 2 (6.1) | - | ||
| H526Y | 9 (27.3) | - | ||
| S531L | 21 (63.6) | - | ||
| INH (n = 43†) | katG (40, 93.0%) | S315T1* | 31 (72.1) | 9 (20.9) |
| inhA (3, 7.0%) | C15T | 2 (4.7) | 1 (2.3) |
*S315T1 means AGC→ACC/Ser→Thr exchange; †includes 33 INH-resistant isolates that were also resistant to RIF, composing 33 MDR isolates.
Abbreviations: INH, isoniazid; MDR, multidrug resistant; RIF, rifampicin.