Table 1:

Platelet G-protein coupled receptors. The table lists the 18 G protein-coupled receptors described in IUPHAR terminology, listed in order of decreasing transcript abundance in human megakaryocytes (18). †Principal coupled G protein. ‡Major CCDS annotated transcript with experimental evidence in megakaryocytes.

Gene Name	Receptor Name	GC content (%)	G-protein†	Protein Accession	Transcript Accession‡
F2R	PAR1	49.8	Gq	ENSP00000321326	ENST00000319211
P2RY12	P2Y12	40.7	Gi	ENSP00000307259	ENST00000302632
PTGIR	IP1	69.0	Gs	ENSP00000291294	ENST00000291294
TBXA2R	TPα	69.6	Gq	ENSP00000364336	ENST00000375190
LPAR5	LPA5	67.9	Gq	ENSP00000327875	ENST00000329858
ADORA2A	A2A receptor	61.3	Gs	ENSP00000336630	ENST00000337539
CXCR4	CXCR4	50.3	Gi	ENSP00000241393	ENST00000241393
F2RL3	PAR4	69.9	Gq	ENSP00000248076	ENST00000248076
P2RY1	P2Y1	51.0	Gq	ENSP00000304767	ENST00000305097
ADRA2A	α2A-adrenoceptor	61.3	Gz	ENSP00000280155	ENST00000280155
CCR4	CCR4	48.2	Gi	ENSP00000332659	ENST00000330953
PTGDR	DP1 receptor	59.9	Gs	ENSP00000303424	ENST00000306051
AVPR1A	V1A receptor	58.9	Gq	ENSP00000299178	ENST00000299178
PTAFR	PAF receptor	53.8	Gq	ENSP00000362965	ENST00000373857
FPR1	FPR1	52.7	Gi	ENSP00000471493	ENST00000304748
PTGER3	EP3 receptor	60.8	Gq	ENSP00000302313	ENST00000306666
SUCNR1	succinate receptor	43.0	Gi	ENSP00000355156	ENST00000362032
HTR2A	5-HT2A receptor	46.0	Gq	ENSP00000437737	ENST00000378688