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. 2015 Jul 21;10(7):e0133274. doi: 10.1371/journal.pone.0133274

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© 2015 Liu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 5 — (A) This shows the average I_to density (I_to = I_to,f + I_to,s) estimated in EPI and ENDO cardiomyocytes isolated from WT and Kv4.2-/- hearts (n = 12 for all groups) using the tri-exponential fitting protocol (described in Fig 1). As we can see, I_to density in Kv4.2-/- was reduced compared to WT for both ENDO and EPI cardiomyocytes. What is striking here is that the transmural gradients of I_to (EPI/ENDO) exist in left ventricular free walls for both WT and Kv4.2-/- but this gradient is markedly reduced in the Kv4.2-/- compared to WT. (B) Again I_to recovery from inactivation curve (n = 12 in each group) was used to separate I_to,f and I_to,s in I_to using the method described in Fig 2. (C) This panel quantifies the I_to,f measured in ENDO and EPI cardiomyocytes from WT and Kv4.2-/- hearts (n = 6 for all groups).