Table 2. Comparison of Ito recovery from inactivation in ventricular myocytes.
| Ito,f | Ito,s | ||
|---|---|---|---|
| ENDO without HpTx-2 | |||
| WT | τrec (ms) | 33±3 | 2256±292 |
| n = 12 | Density (pA/pF) | 7.69 ± 0.87 | 3.78±0.50 |
| Amplitude (%) | 67±9 | 33±9 | |
| Kv4.2-/- | τrec (ms) | 88±10^ | 2267±217 |
| n = 12 | Density (pA/pF) | 3.21±0.31^ # | 3.71±0.39 |
| Amplitude (%) | 45±7 | 55±7 | |
| ENDO with HpTx-2 (5 μM) | |||
| WT | τrec (ms) | 1906±263 | |
| n = 6 | Density (pA/pF) | 4.36±0.93 | |
| Kv4.2-/- | τrec (ms) | 2050±190 | |
| n = 6 | Density (pA/pF) | 4.13±0.75 | |
| EPI without HpTx-2 | |||
| WT | τrec (ms) | 32±4 # | 2187±277 |
| n = 12 | Density (pA/pF) | 27.46±1.38^ # | 0.63± 0.40^ # |
| Amplitude (%) | 98±1 | 2±1 | |
| Kv4.2-/- | τrec (ms) | 86±4 | 2227±310 |
| n = 12 | Density (pA/pF) | 4.64±0.28 | 3.92±0.41 |
| Amplitude (%) | 56±7 | 44±7 | |
^: P<0.05 compared to WT ENDO
#: P<0.05 compared to Kv4.2-/- EPI.